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How effective are topical treatments (calcium channel blockers [CCBs], nitrates, and vitamin E) for chronic anal fissures in adults?
- Quality of compounded topical 2% diltiazem hydrochloride formulations ...
The use of topical 2% diltiazem hydrochloride for treating...
- Quality of compounded topical 2% diltiazem hydrochloride formulations ...
9 wrz 2013 · The use of topical 2% diltiazem hydrochloride for treating anal fissures by lowering anal sphincter pressure has been explored in multiple clinical trials since 2000[1-5]. Diltiazem hydrochloride, a calcium channel blocker, is well known as an oral treatment for hypertension and angina.
22 sty 2013 · The medicine is thought to work by helping the ring muscle (sphincter) that goes around the anus (back passage) to relax and allow blood to flow to the lining of the anus (back passage). This aids the healing process and relieves the pain (see 'What is a chronic anal fissure?').
Anal fissures are considered to be acute if they have been present for less than 6 weeks, super - ficial and have well-demarcated edges. Most of the acute anal fissures heal spontaneously or with conservative medical management. Chronic anal fissures (CAF), on the other hand, persist for more than 6–8 weeks and
22 sty 2013 · How well does topical diltiazem hydrochloride work? In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment.
Topical diltiazem hydrochloride typically comes as a 2% cream or ointment. Topical means that the medicine is applied to the surface of the body, in this case, just inside the anus (back passage).
7 kwi 2012 · Both DTZ and GTN are equally effective in the management of CAF. However, DTZ is associated with a lower incidence of headache and recurrent fissure. Therefore DTZ should be the preferred first line of treatment for CAF.
