Search results
12 lis 2021 · Metformin (1,1-dimethylbiguanide hydrochloride), one of the most common treatments for diabetes, is derived from guanidine and reduces blood glucose levels via AMPK activation . Recently, a mechanism for reducing blood glucose by decreasing bile acid absorption and increasing GLP-1 secretion has also been reported [ 47 ].
1 lut 2022 · Inducing AMPK signaling promotes glucose in DM that is of importance for ameliorating hyperglycemia. Further investigation reveals the role of AMPK signaling in enhancing insulin sensitivity for treatment of diabetic patients.
18 kwi 2024 · AMPK involve in enhance the concentration of glucose transporter like GLUT 1 and GLUT 4 which result in lowering of blood glucose level in influx of blood glucose into the cells; AMPK increases the insulin sensitivity and decreases the insulin resistance and further AMPK decreases the apoptosis of β-cells which result into secretion of insulin a...
31 paź 2022 · The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios.
14 cze 2013 · AMPK activation causes a cell cycle arrest associated with stabilization of p53 and the cyclin-dependent kinase inhibitors p21 WAF1 and p27 CIP1 (63–65).
1 kwi 2016 · As a cellular energy sensor, AMP-activated protein kinase (AMPK) is activated in response to a variety of conditions that deplete cellular energy levels, such as nutrient starvation...
18 kwi 2024 · As AMPK activation leads to overall control of diabetes mellitus, designing and developing of small molecules or peptide that can act as AMPK agonist will be highly beneficial for control or manage diabetes mellitus.
