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Ampicillin (AMP), a semi-synthetic β-lactam antibiotics, is widely used to treat of human and livestock E. coli infection, but recently its resistance rate has increased. 1–3 AMP works on the active replicating stage of bacteria, inhibiting the synthesis of bacterial cell wall.
A recent SENTRY study highlighted the rising rates of ampicillin resistance among contemporary E. faecium isolates (~89.8% worldwide susceptibility) likely associated with the acquisition (and possibly increased expression) of a “resistant” pbp-5 allele (encoding penicillin-binding protein 5) (2, 3, 21).
1 mar 2024 · Advanced spectroscopic techniques such as mass spectrometry (MS), infrared (IR), Raman spectroscopy (RS), fluorescence spectroscopy (FS), and nuclear magnetic resonance (NMR) have shown promising results in the rapid and accurate detection of AMR and AST.
27 maj 2014 · For non-spore-forming gram-positive anaerobes, resistance to metronidazole is common, and ampicillin and penicillin are recommended for primary testing. Although CLSI MIC breakpoints for amoxicillin have not been established for anaerobes, amoxicillin breakpoints are considered equivalent to ampicillin [ 46 ].
To accelerate testing for antibiotic susceptibility, we have developed a new mass spectrometry-based assay for antibiotic susceptibility testing (MAAST). For proof of principle, we present an ampicillin susceptibility test for E. coli with a turnaround time of 90 min upon growth detection.
1 gru 2009 · Some methods provide quantitative results (eg, minimum inhibitory concentration), and all provide qualitative assessments using the categories susceptible, intermediate, or resistant. In general, current testing methods provide accurate detection of common antimicrobial resistance mechanisms.
21 lis 2023 · The 2022 Global Antimicrobial Resistance and Use Surveillance System (GLASS) report highlights alarming resistance rates among prevalent bacterial pathogens. Median reported rates in 76 countries of 42% for third-generation cephalosporin-resistant E. coli and 35% for methicillin-resistant Staphylococcus aureus are a major concern.
