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4 dni temu · antibiotic resistance, loss of susceptibility of bacteria to the killing (bacteriocidal) or growth-inhibiting (bacteriostatic) properties of an antibiotic agent. When a resistant strain of bacteria is the dominant strain in an infection, the infection may be untreatable and life-threatening.
28 lip 2024 · Ampicillin, a commonly used beta-lactam antibiotic, has seen dwindling efficacy due to increasing resistance among various bacterial strains. Understanding how bacteria develop this resistance is crucial for developing new strategies to combat it and ensuring better clinical outcomes.
23 sie 2017 · In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo .
20 wrz 2010 · Antibiotic targets and mechanisms of resistance. See text for details. Resistance to antibiotics occurs through four general mechanisms: target modification; efflux; immunity and bypass; and enzyme-catalyzed destruction (Figure 1).
Examples such as GadA and GadB proteins (glutamate decarboxylase) as well as AmpC and HdeB proteins, which increase ampicillin resistance in E. coli, 63 show the possibilities of different evolutionary pathways for developing antibiotic resistance in bacteria.
21 lis 2023 · Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death.
To provide a comprehensive classification of the antibiotic resistance mechanisms, we will categorize them according to the biochemical route involved in resistance, as follows: (i) modifications of the antimicrobial molecule, (ii) prevention of the compound reaching the antibiotic target (by decreasing penetration or actively extruding the ...
