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4 dni temu · antibiotic resistance, loss of susceptibility of bacteria to the killing (bacteriocidal) or growth-inhibiting (bacteriostatic) properties of an antibiotic agent. When a resistant strain of bacteria is the dominant strain in an infection, the infection may be untreatable and life-threatening.
The journey of antibiotic development and resistance. Key dates for introduction of different penicillin classes and corresponding emergence of resistance are shown (top and bottom, respectively). Examples of different generations of penicillin are indicated and color-coded as in Figure 3.
23 sie 2017 · In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo .
5 wrz 1998 · Antibiotic resistance should be defined in terms of clinical outcomes, not laboratory methods. Resistance occurs by means of four main mechanisms — more than one may be present in a single bacterium. Resistance mechanisms have probably evolved from genes present in organisms producing antibiotics.
21 lis 2022 · Antimicrobial resistance (AMR) is a major global health challenge, causing substantial morbidity and death globally. Understanding the molecular mechanisms that underlie resistance can aid in the...
12 cze 2024 · Antibiotic resistance (AMR) is a global public health threat, challenging the effectiveness of antibiotics in combating bacterial infections. AMR also represents one of the most crucial survival traits evolved by bacteria. Antibiotics emerged hundreds of millions of years ago as advantageous secondary metabolites produced by microbes.
12 cze 2024 · Antibiotic resistance (AMR) represents genetic and biochemical strategies that evade and overcome antibiotics. Abbas, Barkhouse et al. discuss how AMR is a survival trait evolved by bacteria over millennia and readily mobilized across bacterial populations; consequently, AMR is a fundamental threat to how we practice modern medicine and ...
