Search results
The journey of antibiotic development and resistance. Key dates for introduction of different penicillin classes and corresponding emergence of resistance are shown (top and bottom, respectively). Examples of different generations of penicillin are indicated and color-coded as in Figure 3.
12 cze 2024 · Antibiotic resistance (AMR) represents genetic and biochemical strategies that evade and overcome antibiotics. Abbas, Barkhouse et al. discuss how AMR is a survival trait evolved by bacteria over millennia and readily mobilized across bacterial populations; consequently, AMR is a fundamental threat to how we practice modern medicine and ...
23 sie 2017 · In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo .
12 cze 2024 · Antibiotic resistance (AMR) is a global public health threat, challenging the effectiveness of antibiotics in combating bacterial infections. AMR also represents one of the most crucial survival traits evolved by bacteria. Antibiotics emerged hundreds of millions of years ago as advantageous secondary metabolites produced by microbes.
Abstract. Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics.
21 lis 2022 · Introduction. Antimicrobial resistance (AMR) is a major global health challenge, causing substantial morbidity and death globally. Understanding the molecular mechanisms that underlie...
20 wrz 2010 · Antibiotic targets and mechanisms of resistance. See text for details. Full size image. Resistance to antibiotics occurs through four general mechanisms: target modification; efflux; immunity and bypass; and enzyme-catalyzed destruction (Figure 1).
