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31 sie 2000 · In men with osteoporosis, alendronate significantly increases spine, hip, and total-body bone mineral density and helps prevent vertebral fractures and decreases in height.
7 sie 2024 · Alendronate is used in the treatment and prevention of osteoporosis in postmenopausal women and men. Alendronate may also be used to treat glucocorticoid-induced osteoporosis and Paget's disease of the bone.
Alendronic acid is good for your bones – it makes them stronger and less likely to break. You'll usually take it as a tablet or liquid, once a week. Take alendronic acid first thing in the morning, before you have anything to eat or drink and before you take any other medicines.
The pivotal Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly Trial (HORIZON-PFT) showed that a once-yearly infusion of 5 mg intravenous zoledronic acid during a 3-year period significantly reduced the risk of vertebral and hip fractures by 70% (n = 5675, RR = 0.30, CI: 0.24-0.38) and 41% (RR = 0.59, CI: 0.42-0.83 ...
Subgroup analysis showed that alendronate with a daily dose of 10 mg rather than a weekly dose of 70 mg was associated with greater increase in the BMD of lumbar spine and femoral. Moreover, alendronate significantly reduced the incidence of vertebral fractures when compared with other therapies.
18 mar 2004 · Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized, double-blind study, in which postmenopausal women with osteoporosis were treated...
Alendronic acid: Bisphosphonate; reduces overall bone resorption with impairment of osteoclast (decreased resorption) although some reduction of osteoblast function (bone formation) due to ‘coupling’ 70 mg once-weekly oral tablet (or 10 mg daily), taken on an empty stomach with a full glass of water, remaining upright for 30 minutes after ...
