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Both the Fracture Risk Assessment Tool (FRAX) and measurement of bone mineral density (BMD) via a DEXA scan are routinely used in the assessment of fracture risk in individuals living with HIV, as bone loss is thought to start between the ages of 40 and 50 years old.
19 mar 2023 · HIV modulates the function of inflammatory cells, and this can have a direct impact on bone density. For instance, HIV-infected T-cells can modulate the function of macrophages and lymphocytes and, most importantly, enhance the recruitment of osteoclasts, leading to an increase in RANKL and low expression of osteoprotegerin [41,44].
1 maj 2021 · Purpose of review: People living with HIV (PWH) are at greater risk of low bone mineral density (BMD) and fractures compared to the general population. This narrative review summarises recent literature in the field, including the relative contribution of antiretroviral therapy and frailty to low BMD and fractures in PWH.
26 lip 2024 · Since the development of combined antiretroviral therapy (cART), there has been a tendency toward an increasing percentage of people living with HIV/AIDS (PLWHIV) over the age of 50, which is accompanied by an increased risk of bone fracture in this population [1, 2, 3].
20 cze 2022 · People living with HIV (PLWH) are at an increased risk for osteoporosis, a disease defined by the loss of bone mineral density (BMD) and deterioration of bone quality, both of which independently contribute to an increased risk of skeletal fractures.
Their increased risk of bone loss has resulted in a higher incidence of fractures in adults living with HIV (Gonciulea et al., 2017; Sharma et al., 2015), prompting clinician assessment and intervention to improve bone density. To date, the majority of studies and clinical interventions have included pharmacological agents to treat bone loss ...
26 lip 2024 · Introduction. Since the development of combined antiretroviral therapy (cART), there has been a tendency toward an increasing percentage of people living with HIV/AIDS (PLWHIV) over the age of 50, which is accompanied by an increased risk of bone fracture in this population [1, 2, 3].
