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Breakthroughs in the prevention of HIV important to public health include male medical circumcision, antiretrovirals to prevent mother-to-child transmission, antiretroviral therapy in people with HIV to prevent transmission, and antiretrovirals for pre-exposure prophylaxis.
1 cze 2014 · Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell...
1 wrz 2011 · Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses, human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the origins and evolution of...
1 lut 2017 · From Africa, HIV rapidly spread in the late 1960s to the Caribbean and then the United States, Europe, and other areas of the world, leading to the global AIDS pandemic. Both HIV-1 and HIV-2 descended genetically from Simian immunodeficiency virus via cross-species transmission.
Research has deepened our understanding of how the virus replicates, manipulates, and hides in an infected person. Although our understanding of pathogenesis and transmission dynamics has become more nuanced and prevention options have expanded, a cure or protective vaccine remains elusive.
Vertical transmission of HIV-2 is closely correlated with elevated plasma viral load (VL). Similarly, shedding of HIV-2 in genital secretions is significantly lower for HIV-2 and the levels of HIV-2 in semen are closely related to plasma VL [15].
1 cze 2021 · Explain how HIV evolved from cross-species transmission of strains of simian immunodeficiency virus (SIV) to humans (viral zoonosis), spread out of Africa in the early 20th century, and eventually resulted in the global AIDS pandemic
