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4 lip 2024 · Acute disseminated encephalomyelitis (ADEM), as the name would suggest, is featured by a monophasic acute inflammation and demyelination of white matter typically following a recent (1-2 weeks prior) viral infection or vaccination 4,6.
Acute disseminated encephalomyelitis (ADEM) a monophasic autoimmune demyelinating disease of the central nervous system that occurs after a febrile infection or vaccination. Typically, ADEM manifests as multifocal high T2WI/ FLAIR signal lesions mimicking multiple sclerosis (MS).
26 sty 2024 · Most cases of ADEM are monophasic with 1 single event. The clinical severity may fluctuate within 3 months. If there is another episode of inflammatory demyelination after 3 months, the diagnosis is multiphasic ADEM.
23 cze 2024 · Acute Disseminated Encephalomyelitis (ADEM) is an immune-mediated inflammatory disorder of the central nervous system, typically following a viral infection or vaccination. It is characterised by widespread demyelination, primarily affecting the white matter of the brain and spinal cord.
In the acute stages, ADEM is characterized histologically by perivenous edema, demyelination, and infiltration with macrophages and lymphocytes, with relative axonal sparing, whereas the late course of the disease is characterized by perivascular gliosis.
W terapii ADEM, nakierowanej bardziej swoiście, znajdują zastosowanie dwie podstawowe metody – duże dawki kortykosteroidów oraz plazmafereza. Kortykosteroidy w postaci wlewów dożylnych metyloprednizolonu stosuje się u osoby dorosłej przez przynajmniej 5 dni w dawce od 0,5 g do 1,0 g dziennie.
In the acute stages, ADEM is characterized histologically by perivenous edema, demyelination, and infiltration with macrophages and lymphocytes, with relative axonal sparing, whereas the late course of the disease is characterized by perivascular gliosis.
