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Acquired aplastic anemia is a T-cell mediated autoimmune disease, in which regulatory T cells are decreased and T-bet, a transcription factor and key regulator of Th1 development and function, is upregulated in affected T-cells.
16 mar 2017 · Acquired severe aplastic anemia (SAA) is a rare hematologic disease associated with significant morbidity and mortality. Immune destruction of hemopoietic stem cells plays an important role in pathogenesis, as shown by successful treatment with immunosuppressive agents, leading to transfusion independence or complete recovery of peripheral ...
22 cze 2021 · Establishing a diagnosis of aplastic anemia (AA) can be challenging, but it is absolutely critical to appropriate management, especially differentiating between acquired and inherited forms of the disease.
Idiopathic acquired aplastic anemia (aAA) is a rare, life threatening bone marrow failure syndrome characterized by cytopenias and a hypocellular bone marrow. Aplastic anemia (AA) is classified as either inherited or acquired.
11 lis 2017 · Acquired aplastic anemia (AA) is a rare, life-threatening bone marrow failure (BMF) disorder that affects patients of all ages and is caused by lymphocyte destruction of early hematopoietic cells.
4 lut 2024 · Acquired aplastic anemia is an immune-mediated disease that targets hematopoietic stem cells, which is diagnosed by findings of peripheral blood pancytopenia and hypocellular bone marrow.
Acquired aplastic anemia is an anatomic and physiologic failure of the bone marrow leading to pancytopenia. While occasionally the pancytopenia may be associated with a normocellular bone marrow, in the vast majority of the cases, the bone marrow is hypoplastic and pancytopenia is pronounced.
