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21 gru 2021 · Acetaldehyde is an aliphatic aldehyde that exists at room temperature as a colorless gas with a fruity, pungent odor. It is miscible with water, ether, benzene, gasoline, solvent naphtha, toluene, xylene, turpentine, and acetone. It is very flammable and is unstable in air (Akron 2009, HSDB 2009).
No treatment-related systemic toxicity or effects on body-weight gain or on the trachea or lungs were observed. Histologic examinations of the olfactory epithelium showed no effects at 50 ppm, relatively little olfactory neuronal loss at 150-500 ppm, and moderately severe lesions at 1,500 ppm.
It has been detected at low levels in drinking-water, surface water, rainwater, effluents, engine exhaust and ambient and indoor air samples. It is also photochemically produced in surface water. Acetaldehyde is an intermediate product in the metabolism of ethanol and sugars and therefore occurs in trace quantities in human blood.
14 cze 2024 · Chronic and prolonged exposure to large amounts of acetaldehyde can cause serious impairment of body function. This is because this toxin damages many key tissues and organs and is a carcinogen. The oesophagus, large intestine, pancreas and liver are particularly susceptible to carcinogenic effects.
In a 28-day study in which acetaldehyde was administered in the drinking-water to rats, effects were limited to slight focal hyperkeratosis of the forestomach at 675 mg/kg body weight (no-observed-effect level (NOEL): 125 mg/kg body weight).
Page 18, lines 9-11: “Acetaldehyde is an intermediary in the normal catabolism of deoxyribose phosphate and various amino acids. A quantitatively much more important source of acetaldehyde in the body, however, is its formation through the action of alcohol dehydrogenase on ingested ethanol.”
The toxic effects of acetaldehyde are characterized by facial flashing, nausea, vomiting, tachycardia, and hypotension (acetaldehyde syndrome), and the severe or even fatal outcomes of these effects have been reported [, , ].
