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RNA consists of four nitrogenous bases: adenine, cytosine, uracil, and guanine. Uracil is a pyrimidine that is structurally similar to the thymine, another pyrimidine that is found in...
Five nucleobases— adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U)—are called primary or canonical. They function as the fundamental units of the genetic code, with the bases A, G, C, and T being found in DNA while A, G, C, and U are found in RNA.
Hydrogen atoms are not shown. Each nucleotide in RNA contains a ribose sugar, with carbons numbered 1' through 5'. A base is attached to the 1' position, in general, adenine (A), cytosine (C), guanine (G), or uracil (U). Adenine and guanine are purines, and cytosine and uracil are pyrimidines.
1 lis 2013 · Non-canonical base pairs are formed by edge-to-edge hydrogen bonding interactions between the bases. A large number of theoretical studies have been done to detect and analyze these non-canonical base pairs within crystal or NMR derived structures of different functional RNA.
30 kwi 2019 · Noncoding RNA molecules are composed of a large variety of noncanonical base pairs that shape up their functionally competent folded structures. Each base pair is composed of at least two interbase hydrogen bonds (H-bonds).
4 maj 2022 · Concepts related to the nomenclature, hydrogen bonding, pKa, and isostericity of base pairs are a key to understanding the complex structures and functions in RNA. The sugar–phosphate backbone of nucleic acids binds to the heterocyclic, aromatic, nitrogenous bases.
29 lip 2023 · The base pairing via hydrogen bonds is the basis of RNA's secondary structure. The RNA tertiary structure is the result of RNA folding, which creates a three-dimensional shape consisting of helices and grooves.