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Voltage gated calcium channel (VGCC) antibodies are generally associated with Lambert-Eaton myasthenic syndrome. However the presence of this antibody has been associated with paraneoplastic as well as non-paraneoplastic cerebellar degeneration. ...
Introduction: Voltage-gated calcium-channel autoimmunity (VGCC-P/Q and VGCC-N types) occurs beyond Lambert-Eaton syndrome and lung cancer. Methods: We reviewed records for 236 Mayo Clinic patients with VGCC antibodies found in evaluation for paraneoplastic neurological autoimmunity (generally without myasthenic syndromes).
Herein, we present a patient with ACD and VGCC autoantibodies who initially improved with IV immunoglobulin G (IgG) and immunosuppression but who subsequently developed LEMS despite immunosuppressive therapy. The patient's IgG bound to Purkinje cell calcium channels in rat cerebellar slice cultures and produced Purkinje cell death.
Calcium channel antibodies were detected in 3 of 173 healthy control subjects (1.7%) and 10 of 245 neurologically asymptomatic patients with lung cancer (4%). Two healthy controls had VGCC-P/Q antibody (0.10 and 0.18 nmol/L), and 1 had VGCC-N antibody (0.05 nmol/L).
Detect antibodies for P/Q type and N-type voltage-gated calcium channels. Aid in the evaluation of muscle weakness in the context neuromuscular junction disorder with or without cancer, or the diagnosis of paraneoplastic neurological syndromes.
1 lis 2022 · We report the presence of L-type VGCC (L-VGCC) subunit proteins, Cav1.2, α2δ and β in HEK-293 cells and the application of simple methods for its assay. Endogenous expression of the channel in HEK-293 cells overcomes the need for transfection. L-VGCC in HEK-293 cells was activated either by the agonist, BayK8644 or by KCl-mediated depolarization.
6 kwi 2015 · OBJECTIVE: Describe the significance of voltage gated calcium channel antibody (VGCC-Ab) in evaluating neurological disorders. BACKGROUND: Association between VGCC-Ab, Lambert-Eaton Myasthenic Syndrome (LEMS), and small cell lung cancer (SCLC) is well known.
