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The Δ 8 -THC treatment (30 mg/kg) reduced paw swelling and qualitative signs of arthritis. Δ 8 -THC also blocked CIA-depressed climbing and CIA-induced preference for a heated floor without producing locomotor effects but did not affect latency to fall from a wire grid.
- The Cannabinoids Δ 8 THC, CBD, and HU-308 Act via Distinct ... - PubMed
Application of Δ 8 THC, CBD, and HU-308 reduced the pain...
- The Cannabinoids Δ 8 THC, CBD, and HU-308 Act via Distinct ... - PubMed
6 maj 2022 · Delta-8-tetrahydrocannabinol (Δ 8 -THC) is a cannabinoid that is a double bond isomer of the more well-known Δ 9 -THC (Figure 1). Δ 8 -THC was first derived from the cyclization of cannabidiol (CBD) and it was discovered to be highly psychoactive in human studies (Adams, 1942).
Abstract. Patients with arthritis report using cannabis for pain management, and the major cannabinoid delta-9-tetrahydrocannabinol (Δ 9-THC) has anti-inflammatory properties, yet the effects of minor cannabinoids on arthritis are largely unknown.The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid delta-8-tetrahydrocannabinol (Δ 8-THC) using ...
1 lut 2018 · Application of Δ 8 THC, CBD, and HU-308 reduced the pain score and neutrophil infiltration in WT mice. The antinociceptive and anti-inflammatory actions of Δ 8 THC, but not CBD, were blocked by the CB 1 R antagonist AM251, but were still apparent, for both cannabinoids, in CB 2 R-/-mice.
The receptor mechanisms mediating cannabinoid effects in the tetrad are not fully understood. However, transgenic mice with conditional knockouts of different cannabinoid receptors have been widely used to identify the neuronal populations that mediate Δ 9 -THC or other cannabinoid effects.
21 lis 2022 · This report confirms public health and ED providers’ fears: the increase of chronic delta-8 users (who assume delta-8 to be safer) will increase the number of adverse events associated with cannabis use.
1 lut 2018 · Vehicle treatment produced an average pain score of 28±6 (n =8). Different doses of topical Δ 8 THC, CBD, and HU-308 were examined in WT mice to establish the effective drug concentrations required to reduce corneal pain compared to the vehicle-treated group (Fig. 2A).
