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3 lip 2024 · White matter disease can be broadly grouped into: demyelinating disorders. damage and/or destruction of previously normally myelinated structures. e.g. multiple sclerosis, ADEM. dysmyelinating disorders. abnormal structure and function of myelin, usually secondary to a hereditary disorder.
- White Matter Disorders
White matter disorders are conditions that affect the...
- Splenial Demyelinating Lesion
An intrasubstance altered signal intensity of the splenium...
- White Matter Disorders
4 maj 2020 · Our knowledge of white matter diseases is constantly evolving because of the discovery of new disease mechanisms, therapy advances, and refinements in MRI diagnosis and follow-up. In this context, a thorough understanding of MRI patterns is becoming increasingly important.
Vanishing white matter disease (figure 2D–F), CSF1R (figure 2 G–I) and AARS2-related leukodystrophies have relatively specific imaging appearances. Specific signs, such as hypomyelination or prominent posterior fossa abnormalities, may suggest groups of disorders.
4 maj 2020 · This update reviews the 2017 McDonald criteria for diagnosis of multiple sclerosis and the guidelines for MRI follow-up according to risk profile and baseline therapy, as well as new knowledge of neuromyelitis optica spectrum disorders and other white matter diseases.
12 wrz 2016 · White matter diseases include a wide spectrum of disorders that have in common impairment of normal myelination, either by secondary destruction of previously myelinated structures (demyelinating processes) or by primary abnormalities of myelin formation (dysmyelinating processes).
4 maj 2020 · MRI is recommended before initiating or changing MS treatment and at 6 months after treatment initiation to allow the new drug to reach its therapeutic potential. Worsening of lesion activity at MRI is indicative of suboptimal response and could suggest the need for a treatment modification .
MRI has proven to be pivotal in the diagnostic workup of patients with leukoencephalopathies. 2 First, the presence of white matter abnormalities is usually established with MRI. CT may show white matter hypodensity, but it is much less sensitive than MRI and gives no details.
