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DNA ligase is an enzyme that catalyzes the formation of a phosphodiester bond between DNA fragments. It has various types and functions in different organisms, such as repairing DNA damage, replicating DNA, and cloning DNA.
3 sie 2023 · DNA ligase is an enzyme that joins DNA fragments by forming phosphodiester bonds. Learn about its structure, types (ATP-dependent and NAD+ dependent), and functions (DNA replication, repair, and recombination) with examples and references.
24 paź 2024 · DNA ligase is an essential enzyme that plays a critical role in the integrity and maintenance of DNA within living organisms. Its primary function is to facilitate the joining of DNA strands by catalyzing the formation of phosphodiester bonds, a crucial process in DNA repair, replication, and recombination.
DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends via three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes.
DNA ligase is an enzyme that forms a covalent bond between two polynucleotide chains. Learn about its functions, mechanisms, applications, and sources from various chapters and articles on ScienceDirect.
DNA ligase is an enzyme that repairs breaks in the DNA backbone by joining adjacent nucleotides. Learn about its mechanism, structure, functions, and applications in neuroscience and molecular biology.
DNA ligase is an enzyme that repairs DNA breaks by joining the 5´-phosphorylated ends of broken DNA to the 3´-OH ends, repairing breaks in the phosphate backbone of DNA.
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