Search results
30 lip 2020 · Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer cells which enables replicative immortality. In contrast, telomerase activity is silenced in most adult...
- Targeting telomeres: advances in telomere maintenance ... - Nature
Therapies that target telomerase have historically been...
- Targeting telomeres: advances in telomere maintenance ... - Nature
5 lip 2022 · Therapies that target telomerase have historically been viewed as a highly attractive means of cancer treatment by restraining proliferative capacity through telomere length 85,86,87 (Table 1).
21 lip 2016 · Natural and small-molecule telomerase inhibitors, immunotherapeutic approaches, oligonucleotide inhibitors, and telomerase-directed gene therapy are useful treatment strategies. Telomerase is more widely expressed than any other tumor marker.
20 cze 2016 · Here, we summarize telomere organization and function and its role in oncogenesis. We also highlight genomic mutations that lead to reactivation of telomerase, and mechanisms of telomerase reconstitution and trafficking that shed light on its function in cancer initiation and tumor development.
In summary, telomerase and its regulation of telomere length is both an important target for cancer therapy and for the treatment of age-related disease. The telomerase gene will likely have many important applications in the future of medicine and cellular engineering.
12 sie 2020 · Due to its broad and selective expression in cancer cells and its significant immunogenicity, telomerase is considered an ideal universal tumor-associated antigen, and consequently, a very attractive target for anti-cancer immunotherapy.
7 wrz 2023 · From a technical point of view, there are several strategies for the telomerase-based treatment of cancer: oligonucleotide inhibitors, small-molecule telomerase inhibitors, immunotherapeutic approaches, telomerase-directed gene therapy, phytochemicals and various other substances with off-target effects and a broad range of mechanisms.
