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30 lip 2020 · Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer cells which enables replicative immortality. In contrast, telomerase activity is silenced in most adult...
- Targeting telomeres: advances in telomere maintenance ... - Nature
Therapies that target telomerase have historically been...
- Targeting telomeres: advances in telomere maintenance ... - Nature
7 wrz 2023 · Based on new findings and approaches, we propose a concept how long-term survival in telomerase-based cancer therapies can be significantly improved: the TICCA (Transient Immediate Complete and Combinatory Attack) strategy.
5 lip 2022 · Therapies that target telomerase have historically been viewed as a highly attractive means of cancer treatment by restraining proliferative capacity through telomere length 85,86,87 (Table...
16 wrz 2022 · Given the impact of telomere length on cancer, researchers are interested in developing therapies that target telomeres and the proteins controlling their length. Telomerase inhibition . One approach is to inhibit the telomerase enzyme to prevent telomere elongation.
Here we discuss recent efforts targeting telomerase, including immunotherapies and direct telomerase inhibitors, as well as emerging approaches such as targeting TERT gene expression driven by TERT promoter mutations.
21 lip 2016 · Natural and small-molecule telomerase inhibitors, immunotherapeutic approaches, oligonucleotide inhibitors, and telomerase-directed gene therapy are useful treatment strategies. Telomerase is more widely expressed than any other tumor marker.
20 cze 2016 · Interventions targeting the molecules involved in non-telomeric functions of telomerase may be a rational approach for cancer treatment. Inhibition of TRF1 shelterin protein: TRF1 is overexpressed in many cancer types and plays a central role in controlling replication of telomeric DNA.
