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2 mar 2020 · The selective estrogen-receptor modulator tamoxifen is most widely known and used for its role in the adjuvant treatment of breast cancer, but it has also been studied for the management of breast pain at a dose of 10 to 20 mg daily.
The hormone oestrogen can encourage some breast cancer to develop and grow. Tamoxifen is an anti-oestrogen drug. It stops oestrogen attaching to breast cancer cells and making them grow. It only works for breast cancer that is oestrogen receptor positive (ER positive).
8 sty 2020 · Tamoxifen has been shown to be effective in reducing breast pain by 71%–96% in women with cyclic breast pain and 56% of women with noncyclic breast pain . However, tamoxifen carries with it some potentially serious side effects including deep venous thrombosis and endometrial cancer.
17 sty 2011 · Tamoxifen may reduce breast pain but can cause adverse effects. Adverse effects of tamoxifen (hot flushes and GI disturbances) are more likely with higher doses (20 mg) compared with lower doses (10 mg). Long-term use of tamoxifen has been associated with an increased risk of venous thromboembolism.
10 kwi 2023 · For patients taking tamoxifen for breast cancer risk reduction at high risk for breast cancer or ductal carcinoma in situ, it should be avoided if the patient has a history of deep vein thrombosis (DVT) or pulmonary embolism (PE).
Studies in the adjuvant setting have shown that endocrine therapy related side effects predict breast cancer recurrence risk. Here, we assess the relationship between early reported side effects and incidence of breast cancer in women randomised to tamoxifen for cancer prevention in the International Breast Intervention Study (IBIS)–I trial.
8 gru 2022 · This topic review will cover management of the major side effects of tamoxifen and AIs. The use of these agents as hormonal treatment for breast cancer, both in the adjuvant setting and for advanced disease, and their use as chemopreventive agents in women at increased risk for breast cancer are discussed elsewhere.
