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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses...
4 sty 2022 · Components of synthetic RNA devices. A major research focus in synthetic biology is the devel-opment of modular frameworks for constructing geneti-cally encoded devices and engineered...
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
30 lis 2023 · When combined in a network-like structure, RNA devices can form synthetic circuits that can perform even more complex functions such as gene expression regulation 23, signal amplification 24, and...
17 paź 2008 · We developed a general approach for assembling RNA devices that can execute higher-order cellular information processing operations from standard components. The engineered devices can function as logic gates (AND, NOR, NAND, or OR gates) and signal filters, and exhibit cooperativity.
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
16 sty 2023 · Here we present a design strategy for developing synthetic circRNA devices that control circRNA translation in a cell type-specific manner by detecting target miRNAs and RBPs (Figure 1). We designed miRNA- and RBP-responsive circRNA switches by engineering the UTRs and Coxsackievirus B3 (CVB3) IRES and constructed synthetic circRNA circuits for ...
