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SSRIs have low known risk, most experience with fluoxetine and sertraline. TCAs also have low teratogenic risk. Imipramine, nortriptyline and sertraline considered safest in breastfeeding. See section 6.3. *Refer to prescribing notes, page 8
1 maj 2023 · Selective serotonin reuptake inhibitors (SSRIs) are a class of medications most commonly prescribed to treat depression. They are often used as first-line pharmacotherapy for depression and numerous other psychiatric disorders due to their safety, efficacy, and tolerability.
2 gru 2022 · Of the 42 reviews, 28 (67%) assessed and reported the dose-response effects related to acceptability (early treatment discontinuation—dropouts) and tolerability (reported adverse drug effects). All reviews demonstrated that dropouts and adverse drug effects increased with increasing dose (table 2).
Selective serotonin reuptake inhibitors, also called SSRIs, are the type of antidepressant prescribed most often. They can ease symptoms of moderate to severe depression. They are relatively safe, and they typically cause fewer side effects than other types of antidepressants do.
Tables and figures included in the supplement a or referenced in the guideline: Table S1. Evidence linking CYP2D6, CYP2C19 and CYP2B6 genotype to SSRI phenotype. Table S2. Evidence linking CYP2D6 genotype to SNRI and serotonin modulator phenotype. Table S3. Evidence linking SLC6A4 genotype to antidepressant phenotype.
People swapping or stopping antidepressants should be carefully monitored. People should be advised what effects to be mindful of when swapping and when to seek help.
SUMMARY. Switching from one antidepressant to another is frequently indicated due to an inadequate treatment response or unacceptable adverse effects. All antidepressant switches must be carried out cautiously and under close observation.
