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19 kwi 2023 · Regenerating hair cells through gene therapy approach. Studies like Chen’s show the promise of gene therapy for treating incurable conditions like hearing loss.
24 maj 2022 · These studies motivated efforts to identify therapeutic interventions to regenerate hair cells as a treatment for hearing loss, with a focus on targeting supporting cells to form new sensory hair cells.
29 mar 2022 · The MIT spinout Frequency Therapeutics uses a new kind of druggable regenerative therapy that targets progenitor cells to create hair cells of the inner ear and reverse hearing loss.
26 mar 2024 · Sato et al. provide a timetable of the cytomorphological maturation and reinnervation of newly regenerated avian auditory hair cells, leading to functional recovery of hearing thresholds. Synapse reformation happens via an unusual mechanism at the tips of hair cell projections that reach toward afferent neurites near the basement membrane.
Because mammalian hair cells do not regenerate, the repair of hair cell damage is important for continued auditory function throughout life. Here we discuss how several key hair cell structures can be damaged, and what is known about how they are repaired.
3 paź 2023 · Research into anatomy and developmental biology has helped researchers discover and verify the structures and functions of hair cells and has led to novel approaches to regenerating new hair cells from neonatal or adult stem cells and precursor cells.
22 kwi 2022 · We found that AAV-ie-K558R can partially restore the hearing loss in Prestin KO mice and, importantly, deliver Atoh1 into cochlear supporting cells to generate hair cell-like cells.
