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24 maj 2011 · Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more efficacious anti-malarial drugs.
- Evaluating Cinchona bark and quinine for treating and preventing malaria
In this paper, we consider methods used from the 17th to the...
- Clinical pharmacokinetics of quinine and its relationship with ...
The impact of malaria severity on quinine exposure is...
- Evaluating Cinchona bark and quinine for treating and preventing malaria
Quinine is a medication used to treat malaria and babesiosis. [5] This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available.
22 mar 2019 · New drugs are needed, particularly those with new mechanisms of action. Here the range of anti-malarial medicines developed over the years are reviewed, beginning with the discovery of quinine in the early 1800s, through to modern day ACT and the recently-approved tafenoquine.
20 sty 2017 · In this paper, we consider methods used from the 17th to the 21st centuries to assess the effects of Cinchona bark and of quinine and its derivatives for (i) treating and (ii) preventing malaria in individuals and (iii) in attempts to control malaria in populations.
1 lut 2024 · Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing. This medicine may be used alone or given together with one or more medicines for malaria.
24 cze 2024 · Quinine should be given for three days, except for infections acquired in Southeast Asia where seven days of treatment is required. The fourth option, mefloquine, is associated with rare but potentially severe neuropsychiatric reactions when used at treatment dose. We recommend this option only when the other options cannot be used.
10 lut 2022 · The impact of malaria severity on quinine exposure is explained by the significantly lower rate of clearance in cases of complicated malaria (0.06 ± 0.04 l/h/kg) [18–20, 23–25] compared with uncomplicated (0.09 l/h/kg) malaria and healthy subjects (0.24 ± 0.14) .
