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Proteases are key factors in the health and viability of cells, involved in multiple processes, such as replication, transcription, cell proliferation, differentiation, extracellular matrix remodeling, and processing of hormones and biologically active peptides.
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Figure 4 . Journal of Biological Chemistry 2019...
- Reversible Phosphorylation
Herb Tabor was the Editor-in-Chief of the Journal of...
- Milestones in Transcription and Chromatin Published in The Journal of Biological Chemistry
During Herbert Tabor's tenure as Editor-in-Chief from 1971...
- Volume 294, ISSUE 5
Proteases: History, discovery, and roles in health and...
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Chętnie wyświetlilibyśmy opis, ale witryna, którą oglądasz,...
- PPT
1 lut 2019 · Proteases and protein degradation play crucial roles in living systems, and I briefly address future directions in this highly diverse and thriving research area. Keywords: astacins; meprins; metalloprotease; metalloproteinase; protein complex; protein degradation; protein domain; proteinase.
13 maj 2015 · Mitoproteases are highly specific and modulate many biochemical activities that are essential for mitochondrial function and integrity, such as trafficking, processing and activation of...
• Proteases are highly regulated (e.g. transcriptionally, post-translationally,activated,inhibited,andcompartmentalized). • Proteases are involved in many diseases (e.g. cancer, Alz-heimer’s, arthritis, blood clotting disorders, allergies, and infections, to name a few). • Protease inhibitors are useful medically (e.g. angiotensin-
Thus, proteases regulate the fate, localization, and activity of many proteins, modulate protein-protein interactions, create new bioactive molecules, contribute to the processing of cellular information, and generate, transduce, and amplify molecular signals.
First volume to comprehensively explore the role of proteases in various diseases; Provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development
Impaired or dysregulated function of mitoproteases is associated with ageing and with many pathological conditions such as neurodegenerative disorders, metabolic syndromes and cancer. A better understanding of the mitochondrial proteolytic landscape and its modulation may contribute to improving human lifespan and 'healthspan'.
