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Intrathecal administration may result in convulsions. Guinea pigs, chinchillas, birds, snakes, and turtles are sensitive to procaine penicillin. The use of broad-spectrum penicillins may lead to superinfection, and GI disturbances may occur after PO administration of ampicillin.
- Antimicrobial Drug Factors for Animals
Examples include mutated penicillin-binding proteins that...
- Antimicrobial Drug Factors for Animals
21 gru 2017 · This chapter briefly reviews the history and current use of antimicrobials in animals, with a focus on food animals in the more economically developed countries. It identifies some of the differences between human medical and food animal use, particularly in growth promotional and “subtherapeutic” use of medically-important antibiotics in ...
Examples of applications in veterinary medicine: Erythromycin: drug of choice against Campylobacter jejuni. Can be an alternative to penicillin in penicillin-allergic animals and second choice for anaerobic infections. Tylosin and spiramycin: used against Mycoplasma infections; used as growth promotants.
Examples include mutated penicillin-binding proteins that confer methicillin resistance to staphylococci, mutations in DNA gyrases that confer resistance to fluoroquinolones, and mutations in ribosomal subunits that confer resistance to various ribosomal inhibitors.
Penicillin is highly antigenic and, in 1956, it was estimated by FDA that some 10 % of the US population had a “proneness” to become sensitive during their lifetime to some food, drug, cosmetic or other substances (Welch, 1957). This was especially significant for penicillin, because of the high frequency of penicillin residues, in up to 10 ...
Examples of appropriate compounding in veterinary practice include mixing 2 approved drugs, preparing an oral paste or suspension from crushed tablets, or adding flavoring to an approved drug.
Animal Research. Areas of research. Research by disease. Penicillin. Florey and Chain first tested the effects of penicillin in mice in 1940. By 1941, penicillin was being used to treat dying soldiers. This research won the Nobel Prize in 1945.
