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[8] [9] Its elimination half-life is 60 to 80 hours. [8] [9] The renal clearance of memantine is dependent on urinary pH. [8] [9] More alkaline urine slows the elimination of memantine, whereas more acidic urine accelerates its elimination. [8] [9]
2 mar 2007 · Memantine is well absorbed from the gastrointestinal tract after oral administration, and its absorption is unaffected by food (Forest Laboratories 2003). It reaches a maximum plasma concentration (Cmax) after a single dose in 3–7 hours, and it has a plasma half-life of about 60–80 hours.
17 lut 2015 · Memantine has a long elimination half-life of approximately 70 hours, which results in little peak-to-trough concentration variations between doses at steady state (after 2 weeks of therapy). 2, 6-8 The soon-to-be-discontinued memantine tablets have been given once daily, which can promote medication adherence and appears to be well tolerated ...
9 paź 2023 · Half-life. Terminal half-life is approximately 60–80 hours. Special Populations. In patients with moderate hepatic impairment (Child-Pugh class B), no change in memantine exposure observed; however, terminal half-life was increased by about 16%. Pharmacokinetics not evaluated in patients with severe hepatic impairment.
31 sty 2024 · The elimination half-life is about 60 to 80 hours. Approximately 48% of the drug administered is eliminated unchanged in the urine. The remaining portion is transformed into 3 polar metabolites with minimal NMDAR antagonistic activity.
The terminal elimination half-life of memantine ranges from 60 to 80 hours in humans. 8,12 Following administration of a single oral dose of 10 mg/kg memantine in rats, the elimination half-life was 2.36 ± 0.20 hours.
All of these findings might indicate that the apparent synergistic antinociceptive effects could depend on the duration of the pain and the pharmacokinetics of the opioid – morphine has a much longer in vivo half life than fentanyl – and the associated development of rapid tolerance .
