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20 lut 2024 · A growing consensus that the brain is a mechanosensitive organ is driving the need for tools that mechanically stimulate and simultaneously record the electrophysiological response of neurons...
19 lip 2020 · MIT researchers have developed a way to induce mechanical stimulation of neural cells, which could lead to new therapeutic treatments. The advance, led by Polina Anikeeva, activates magnetic nanodiscs using an external magnetic field, providing a research tool for studying neural responses.
24 lis 2023 · Mechanical stimulation is a promising means to non-invasively excite and modulate neuronal networks with a high spatial resolution. Despite the thorough characterization of...
26 lip 2021 · The sensory neurons of touch can be categorized in terms of their preferred mechanical stimulus and their force threshold for spike initiation, their rate of adaption to static...
14 lis 2023 · Neuronal activity is regulated by mechanical signals at many levels. For example, in Drosophila photoreceptors, the absorption of light leads to conformational changes in the photosensitive molecule rhodopsin, which activates the enzyme phospholipase C, whose activity leads to changes in the physical properties of the cell membrane.
Seemingly, neuronal networks can differentiate and respond to specific characteristics of mechanical stimulation. Ultimately, the developed multiparametric tool opens the door to explore manifold nanomechanobiological responses of neuronal systems and new ways of mechanical control.
20 sty 2021 · Naturalistic mechanical stimuli activate large overlapping ensembles of neurons. •. In situ hybridization after functional imaging maps responses to cell class. •. Tuning properties of the classes reveal a transcriptomic basis for specialization. •. Mechanotransduction via Piezo2 contributes to almost all aspects of touch. Summary.
