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6 sty 2024 · LogD = LogP − log (1 + 10 (pH − pKa) δ i) where δ i = {1, − 1} for acids and bases, respectively. The astute reader will notice that only a single pKa is provided here which is the global pKa. In Figure 4 I show how the LogD varies with pH for two acidic and two basic drugs.
12 sty 2019 · Measurement of LogP can be undertaken in a variety of ways, the most common is the shake-flask method, which consists of dissolving some of the solute in question in a volume of octanol and water, shaking for a period of time, then measuring the concentration of the solute in each solvent.
In order to accurately measure and report lipophilicity, the scientist must take great care in measurement of logP at a pH where the compound exists in its neutral form (>pH 12 in the case of 5-Methoxy-2-(1-piperidin-4-ylpropyl)pyridine), and/or report logD at a specific pH.
14 gru 2022 · The log P and log D of a compound are functional parameters for assessing the bioavailability of a drug. Log P is a ratio of the compound’s solubility in water vs. its solubility in 1-octanol. Log D is calculated similarly but also considers the ionized form of the drug in the water of a certain pH.
'LogD' refers to the measurement used in chemistry to understand the changes in lipophilicity of a compound due to structural modifications. It helps in interpreting the effects of different chemical contexts on the distribution of a compound between water and oil phases. AI generated definition based on: Comprehensive Medicinal Chemistry III, 2017
19 paź 2017 · A liquid chromatographic method to measure logD7.4. The method differs from some published chromatographic alternatives in the rigour with which the pH of the mobile phase is controlled...
Log P and log D were determined by shake flask method, wherein, the compound was partitioned between presaturated noctanol and water phase (water/PBS pH 7.4) and the concentration of compound in each phase was determined by HPLC.
