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1. academic.oup.com › cardiovascres › advance-articleInterleukin 11 therapy causes acute left ventricular dysfunction

   academic.oup.com › cardiovascres › advance-article

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   9 paź 2024 · Injection of IL11 directly activates IL11RA/JAK/STAT3 in cardiomyocytes to cause acute heart failure. Our data overturn the earlier assumption that IL11 is cardioprotective and explain the serious cardiac side effects associated with IL11 therapy.

2. en.wikipedia.org › wiki › Interleukin_11Interleukin 11 - Wikipedia

   en.wikipedia.org › wiki › Interleukin_11

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   Interleukin 11 (IL-11 or adipogenesis inhibitory factor [5]) is a protein that in humans is encoded by the IL11 gene. [6] IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells.

3. scitechdaily.com › breakthrough-in-anti-aging-il-11-deactivation-boosts-lifespanBreakthrough in Anti-Aging: IL-11 Deactivation Boosts ... -...

   scitechdaily.com › breakthrough-in-anti-aging-il-11-deactivation-boosts-lifespan

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   30 lip 2024 · Working alongside colleagues at Duke-NUS Medical School in Singapore, they tested the effects of IL-11 by creating mice that had the gene-producing IL-11 (interleukin 11) deleted, which extended the lives of the mice by over 20% on average.

4. www.nature.com › articles › d41586/024/02298-5Mice live longer when inflammation-boosting protein is blocked -...

   www.nature.com › articles › d41586/024/02298-5

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   17 lip 2024 · Although a research team tested for these health effects only in mice, IL-11 and its molecular partners — which include chemical messengers for the immune system called interleukins — also...

5. newatlas.com › medical › anti-aging-interleukin-11Anti-aging drug extends life up to 25%, staves off frailty and...

   newatlas.com › medical › anti-aging-interleukin-11

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   18 lip 2024 · Does it reduce or reverse signs and effects of aging, or just prevent further effects? How often would it have to be given, and in what dosage(s)?

6. www.sciencealert.com › blocking-one-protein-extends-lifespan-in-mice-by-up-to-25Blocking One Protein Extends Lifespan in Mice by Up to 25%, Study...

   www.sciencealert.com › blocking-one-protein-extends-lifespan-in-mice-by-up-to-25

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   24 lip 2024 · A protein called interleukin 11 (IL-11) appears to play a crucial role in aging, with scientists extending the lifespans of mice by up to 25 percent simply by blocking the molecule's effects.

7. lms.mrc.ac.uk › scientists-find-master-switch-which-could-hold-the-key-to-longerScientists find “master switch” which could hold the key to...

   lms.mrc.ac.uk › scientists-find-master-switch-which-could-hold-the-key-to-longer

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   17 lip 2024 · The scientists, working with colleagues at Duke-NUS Medical School in Singapore, tested the effects of IL-11 by creating mice that had the gene producing IL-11 (interleukin 11) deleted. This extended the lives of the mice by over 20% on average.