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1. en.wikipedia.org › wiki › Interleukin_11Interleukin 11 - Wikipedia

   en.wikipedia.org › wiki › Interleukin_11

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   The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6 -type cytokine family, distinguished based on their use of the common co-receptor gp130.

2. www.genecards.org › cgi-bin › carddispIL11 Gene - GeneCards | IL11 Protein | IL11 Antibody

   www.genecards.org › cgi-bin › carddisp

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   2 paź 2024 · IL11 (Interleukin 11) is a Protein Coding gene. Diseases associated with IL11 include Hemorrhagic Cystitis and Plasmacytoma . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

3. pubmed.ncbi.nlm.nih.gov › 38054591Understanding interleukin 11 as a disease gene and therapeutic...

   pubmed.ncbi.nlm.nih.gov › 38054591

   13 gru 2023 · Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is redundant for haematopoiesis and toxic.

4. www.sciencedirect.com › org › scienceUnderstanding interleukin 11 as a disease gene and therapeutic...

   www.sciencedirect.com › org › science

   IL11 is not detected in health but is up-regulated, as an alarmin-like response to toxic, genetic, infective, mechanical, oxidative or metabolic disease factors. IL11 signalling pathways converge to cause mesenchymal transitions and a pro-inflammatory state across cell types.

5. www.annualreviews.org › content › journalsHiding in Plain Sight: Interleukin-11 Emerges as a Master...

   www.annualreviews.org › content › journals

   A novel large deletion encompassing the whole of the galactose-1-phosphate uridyltransferase (GALT) gene and extending into the adjacent interleukin 11 receptor alpha (IL11RA) gene causes classic galactosemia associated with additional phenotypic abnormalities.

6. www.nature.com › articles › s41586/024/07701-9Inhibition of IL-11 signalling extends mammalian healthspan and...

   www.nature.com › articles › s41586/024/07701-9

   17 lip 2024 · IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.

7. www.nature.com › articles › s41467/021/22450-3Interleukin-11-expressing fibroblasts have a unique gene...

   www.nature.com › articles › s41467/021/22450-3

   16 kwi 2021 · Human cancer database analysis reveals that the expression of genes enriched in IL-11+ fibroblasts is elevated in human colorectal cancer and correlated with reduced recurrence-free survival.