Search results
17 lip 2024 · The magnitude of lifespan extension remains to be fully determined but current data suggest that anti-IL-11 therapy given in late life increases median lifespan by more than 20% in both sexes.
- IL-11 as a master regulator of ageing - Nature
For example, inhibition of IL-11 improved metabolism and...
- Blocking IL-11 improves healthspan and lifespan in mice
In both male and female mice, the authors found that genetic...
- IL-11 as a master regulator of ageing - Nature
In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%.
20 paź 2024 · We highlight a recent study published in Nature which explored the role of interleukin-11 (IL-11), a pro-inflammatory cytokine, in aging. 1 The study demonstrates how inhibiting IL-11 signaling can positively impact both healthspan and lifespan in mice, suggesting a novel target for antiaging therapies with significant implications for ...
16 paź 2024 · For example, inhibition of IL-11 improved metabolism and muscle function, reduced ageing biomarkers and frailty, and led to an increase in lifespan.
10 wrz 2024 · In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.
8 sie 2024 · In both male and female mice, the authors found that genetic or pharmacological blockade of IL-11 robustly extended median lifespan (by around 20% or more), with a reduced tumor burden upon...
18 lip 2024 · Blocking IL-11 signaling extends lifespan and healthspan in mice, reducing age-related metabolic decline, frailty, and cancer incidence.
