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23 wrz 2021 · Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
Overview. Pharmacokinetics is the term that describes the four stages of absorption, distribution, metabolism, and excretion of drugs. Drugs are medications or other substances that have a physiological effect when introduced to the body.
If trough level is too low, increase dosage by adjusting either the dose or the dose interval; If trough level is too high, withhold the dose until the trough level is in target range and restart at a reduced dose; Continuous infusion of vancomycin is especially useful for patients requiring higher or more frequent doses; Intermittent ...
We present a case of vancomycin nephrotoxicity with simultaneous histological lesions of ATIN and ATN confirmed by renal biopsy, originated by vancomycin intoxication related to the highest plasma trough levels described in literature.
A trough level can be pertinent when the concentration–effect relationship suggests that efficacy (or toxicity) of a drug is linked to the maintenance of blood concentrations above a predefined targeted concentration (glycopeptides, antiviral or antiretroviral drugs, for instance). From: Therapeutic Drug Monitoring, 2012
Studies have shown that when serum vancomycin levels are maintained above 10 mcg/mL, the emergence of vancomycin intermediate-resistant S. aureus and vancomycin-resistant S. aureus are less likely to develop. 2 Consensus guidelines recommend a target trough concentration of 15 to 20 mcg/mL for clinical success in severe infections. 2 To reach ...
