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5 lut 2010 · Furosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain. This review summarises the pharmacology of furosemide, its potential uses and side effects, and the evidence of its efficacy.
Furosemide causes greater loss of water than sodium loss, resulting in the production of hypotonic urine. Loop diuretics also cause increased urinary excretion of potassium, calcium, and magnesium by inhibiting the passive reabsorption of these ions.
24 lip 2019 · Acute kidney injury (AKI) constitutes a serious clinical hazard in critically ill patients. There are multiple acknowledged risk factors for AKI which can be found in the intensive care unit (ICU) setting, including sepsis, circulatory shock, trauma, and use of nephrotoxic drugs [1].
2 wrz 2023 · Furosemide, a frequently prescribed diuretic for managing congestive heart failure and edema, remains a topic of debate regarding its potential risk of inducing acute kidney injury (AKI) in patients.
20 kwi 2022 · Furosemide is typically given twice to four times a day in ICU but can also be given as a continuous infusion in efforts to overcome the post-diuretic salt-avid state of the kidney. There are theoretical benefits to bolus dosing in that a higher peak dose is reached in the renal tubular system.
24 lip 2019 · The use of high-dose furosemide to convert oliguric to non-oliguric AKI may exacerbate injury to the kidneys (increased markers of oxidative stress), especially in hypovolaemic patients with reduced renal perfusion .
4 mar 2020 · Furosemide administration was associated with improved short-term survival and recovery of renal function in critically ill patients with AKI. Furosemide was especially effective in patients with AKI UO stage 2–3 degree.
