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Fatty acid binding protein 7 (FABP7) expressed by astrocytes in developing and mature brains is involved in uptake and transportation of fatty acids, signal transduction, and gene transcription. Fabp7 knockout (Fabp7 KO) mice show behavioral phenotypes reminiscent of human neuropsychiatric disorders ….
9 wrz 2023 · FABP7 expression is largely restricted to astrocytes and radial glia-like cells in the adult central nervous system. We observed that treatment of primary hippocampal astrocyte cultures with amyloid β fragment 25–35 (Aβ 25–35) induces FABP7 upregulation.
FABP7 expression is largely restricted to astrocytes and radial glia-like cells in the adult central nervous system. We observed that treatment of primary hippocampal astrocyte cultures with amyloid β fragment 25-35 (Aβ 25-35) induces FABP7 upregulation.
14 wrz 2021 · FABP7, also known as brain lipid-binding protein (BLBP), is a transporter expressed by injured astrocytes and a marker of Bergmann glia and radial glia [132,133]. In astrocytes from the spinal cord it induces a pro-inflammatory phenotype that renders these cells toxic to motor neurons in coculture .
In the spinal cord of symptomatic mutant hSOD1-expressing mice, FABP7 is upregulated in gray matter astrocytes. Using a coculture model, we examined the effect of increased FABP7 expression in astrocyte-motor neuron interaction.
19 cze 2023 · (4) Astrocyte caveolae formation is driven by FABP7-mediated acetylation of histones via an ATP-citrate lyase (ACLY) interaction that increases nuclear Acetyl-CoA levels and activates the promoter of the caveolin-1 gene.
19 sie 2020 · Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular stimuli by controlling the expression of caveolin-1, an important component of lipid raft.
