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The functional unit of the thyroid gland is the follicle, a roughly spherical group of cells arranged around a protein-rich storage material called colloid. The follicular cells are orientated with their bases near the capillary blood supply and the apices abutting the colloid.
5 gru 2022 · Localization of endogenous thyroperoxidase in thyroid follicles acts as an indicator of iodination during the synthesis of the thyroid hormones. Cytochemical staining of C and oxyphil cells serve as diagnostic markers for tumor, teratoma, and cyst formation in the thyroid gland.
The Thyroid Follicle. The thyroid gland displays a peculiar, highly-organized architecture characterized by the presence of spheroidal structures known as follicles. The follicles are supported by an interfollicular extracellular matrix and a capillary network.
2 wrz 2015 · The production of thyroid hormones is based on the organization of thyroid epithelial cells in functional units, the thyroid follicles. A single layer of polarized cells (Fig. 2-4A) forms the enveloppe of a spherical structure with an internal compartment, the follicle lumen.
18 mar 2019 · This paper suggests that lysosomal degradation of thyroglobulin and thyroid hormone transporter proteins in the thyroid gland are physiologically regulated.
17 lis 2022 · The generation of functional human thyroid follicles from hESCs in vitro has proven to be extremely challenging, compared to mouse-derived equivalents.
19 kwi 2021 · Thyroid Lineage Specification in the Ventral Foregut Endoderm. The thyroid hormone producing cells of the mature gland are thyroid follicular epithelial cells that originate from a small pool of progenitors in the foregut endodermal tube early in embryonic development.
