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15 lip 2019 · Early onset pre-eclampsia arises owing to defective placentation, whilst late onset pre-eclampsia may center around interactions between normal senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease.
29 lip 2024 · Several subtypes of preeclampsia may exist, with a variety of pathophysiological pathways leading to maternal and fetal mortality and morbidity [8]. The most commonly described subtypes are early onset (<34 weeks of gestation) and late onset (≥34 weeks of gestation).
Early-onset preeclampsia is usually defined as preeclampsia that develops before 34 weeks of gestation, whereas late-onset preeclampsia develops at or after 34 weeks of gestation. Although the presenting features overlap, they are associated with different maternal and fetal outcomes, biochemical markers, heritability, and clinical features.
29 mar 2021 · For example, early and late onset preeclampsia are increasingly acknowledged as different pathophysiological processes leading to a common presentation. Other subtypes of preeclampsia are supported by disparate clinical outcomes, long-range prognosis, organ systems involved, and risk factors.
17 wrz 2019 · This comprehensive cohort study demonstrates that EOP and LOP do not meet the same diagnostic criteria. Early-onset preeclampsia poses a high risk of maternal neurological, cardiorespiratory, and hematological complications as well as adverse fetoplacental conditions and complications.
21 mar 2024 · Pre-eclampsia is a hypertensive syndrome that occurs in pregnant women, most often after 20 weeks' gestation, which consists of new-onset, persistent hypertension with either proteinuria or evidence of systemic involvement.
If a woman diagnosed with pre-eclampsia is at an early gestation, the mainstay is expectant management with timing of birth planned to optimise maternal and fetal outcomes. New trials and cohort studies have given insights into the prevention of pre-eclampsia, diagnostic and prognostic tools, and the optimal gestation to plan birth.
