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20 lis 2020 · The most widely studied tolerogenic therapy for coeliac disease, Nexvax2, is a therapeutic vaccine composed of three gluten peptides encompassing five HLA-DQ2-restricted epitopes frequently ...
Recommendations about potential, silent, and seronegative celiac disease. GFD: Gluten-free diet; HLA: Human leukocytes antigen. Silent CD is characterised by the presence of both positive serology and histology for CD in the absence of classical or non-classical symptoms.
Multiple investigational therapies ranging from tolerogenic to immunological approaches are in the pipeline, and several drug candidates have entered phase II/III clinical trials. This Review gives a broad overview of the different investigative treatment modalities for coeliac disease and summarizes the latest advances in this field.
This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed.
At present, strict and lifelong gluten-free diet is the only effective treatment for celiac disease (1). Even small amounts of gluten (50 mg/day) can be immunogenic; therefore all food and food items and drugs that contain gluten and its derivatives must be eliminated from the diet completely (2). While prescribing gluten-free diet is easy; the ...
In recent years, there has been extensive research conducted in the quest to find the holy grail of pharmacological treatment for CD. This review will present a concise description of the current rationale and main clinical trials related to CD drug therapy. Keywords: celiac disease, gluten-free diet, pharmacological treatments. 1. Introduction
The only treatment for a patient with celiac disease is a strict gluten-free diet. A lifelong diet completely free of gluten can be very costly and challenging. Future therapies currently in the pipeline hope to make living with celiac disease less of a burden.
