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20 gru 2019 · This activity covers ciprofloxacin, a broad-spectrum quinolone antibiotic that members of the interprofessional team need to review its indications, coverage, contraindications, and adverse event profile to optimally manage patients' infectious diseases.
28 sie 2023 · This activity covers ciprofloxacin, a broad-spectrum quinolone antibiotic that members of the interprofessional team need to review its indications, coverage, contraindications, and adverse event profile to optimally manage patients' infectious diseases.
Ciprofloxacin is a broad spectrum fluoroquinolone antibacterial agent. Since its introduction in the 1980s, most Gram-negative bacteria have remained highly susceptible to this agent in vitro; Gram-positive bacteria are generally susceptible or moderately susceptible.
Ciprofloxacin is one of a new generation of fluorinated quinolones structurally related to nalidixic acid. The primary mechanism of action of ciprofloxacin is inhibition of bacterial DNA gyrase.
The increasing incidence of ciprofloxacin-resistant pathogens jeopardizes the continued empiric use of ciprofloxacin and raises the urgent need to develop novel ciprofloxacin derivatives potent against both drug-susceptible and drug-resistant pathogens and discover useful synergism between ciprofloxacin and other antibacterial agents.
Ciprofloxacin (international brand names: Cipro, Ciprobay, Ciproxin, Ciproxan, Bactiflox, etc.) is a broad-spectrum antibiotic of the semisynthetic fluoroquinolone class. It is one of the most widely used antibiotics in the world because of its efficacy, safety, and relatively low cost.
22 cze 2021 · Ciprofloxacin is commonly prescribed as a front-line treatment against a broad range of bacterial infections ( 2, 3 ). Quinolone antibiotics target bacterial DNA gyrase (GyrA/GyrB) and topoisomerase IV (ParC/ParE), enzymes which control DNA supercoiling during replication and transcription.
