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13 kwi 2023 · Metastasis, the growth of cancer cells in organs distant from the one in which they originated, is the ultimate and most lethal manifestation of cancer. The vast majority of cancer patients die as a consequence of their metastatic disease and not due to primary tumors.
- Impact of Risk Factors on Early Cancer Evolution
Caloric restriction can somewhat rescue cytotoxic T cell...
- Unity in Heterogeneity
Tumor cells do not exist in isolation in vivo, and...
- Volume 186, ISSUE 8
Metastasis is the most lethal manifestation of cancer, but...
- PDF
Chętnie wyświetlilibyśmy opis, ale witryna, którą oglądasz,...
- Emerging Biological Principles
Recent genomic studies have often revealed close genetic...
- Impact of Risk Factors on Early Cancer Evolution
13 kwi 2023 · Metastasis requires the acquisition of a succession of traits to disseminate, variably enter and exit dormancy, and colonize distant organs. The success of these events is driven by clonal selection, the potential of metastatic cells to dynamically transition into distinct states, and their ability to co-opt the immune environment.
12 mar 2020 · The development of secondary tumors in a part of the body that is far from the original primary cancer is termed “metastasis.” Despite metastasis being the key cause of failure of...
Recent genomic studies have often revealed close genetic relationships between primary tumors and metastases in a variety of cancer types, implying that, at least in certain cases, the cells forming a metastatic colony derive from a dominant clonal subpopulation within the primary tumor that managed to complete all of the steps required both ...
24 mar 2021 · The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target metastasis.
1 gru 2022 · In spontaneous models, the cancer cells spread from a primary tumor to a secondary site. In experimental metastasis models, cancer cells are injected intravascularly, bypassing primary tumor formation.
4 sty 2021 · Initiation of metastasis relies on the tumor cell cross-talking with stromal cells and taking an epithelial-mesenchymal transition (EMT) in single cells, and a hybrid EMT in collective migratory cells.
