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6 maj 2024 · New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development of specialized research strategies, treatment approaches and...
6 maj 2024 · The study on APOE4 homozygosity indicates a genetic variant of Alzheimer’s disease with early symptom onset and distinct biomarker progression, highlighting the need for specialized...
10 maj 2024 · In this paper, scientists led by Juan Fortea and Victor Montal suggest that homozygosity for APOE ε4 constitutes a genetically determinant form of AD similar to autosomal dominant forms of AD, and that their results will have compelling consequences for public health and genetic counseling.
Relative to the most common APOE ε3 homozygous genotype (reference group), possessing one APOE ε4 allele increases the risk of developing Alzheimer's disease by approximately 3·7 times and being homozygous for the APOE ε4 allele increases the risk up to 12 times, whereas carrying a single APOE ε2 allele reduces the risk by approximately 40%, and...
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD.
14 maj 2024 · People who carry two APOE4 copies, called APOE4 homozygotes, have been estimated to have a 60% chance of developing AD dementia by age 85. While APOE4 homozygotes account for only about 2% of the overall population, they make up a larger share of AD cases—an estimated 15%.
11 sty 2024 · Based on their new study, however, the Span-ish research team argue that APOE4 homozygosity should be viewed as a distinct, genetic form of AD, as 95% of people carrying two copies of APOE4 have amyloid plaques in the brain by age 65.
