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7 maj 2008 · Stimulating the NMDA Receptor Makes Pain Worse. Amantadine was first used as an antiviral medication against influenza, but it is mainly used now for its ability to block something called an “NMDA receptor.”. The NMDA receptor is involved in creating inappropriate pain.
- Gabapentin & Amantadine - Veterinary Information Network (VIN)
One study in dogs with osteoarthritis-related pain...
- Gabapentin & Amantadine - Veterinary Information Network (VIN)
Gabapentin and amantadine are used as part of analgesic protocols for chronic pain relief in dogs and cats. This article describes the types of pain, the reasons why chronic pain can be difficult to treat, and the use of gabapentin and amantadine for treatment of chronic pain.
Its use in small animals is primarily for the treatment of pain, and it is often paired with other pain medications such as non-steroidal anti-inflammatory drugs (NSAIDs), opioids, or gabapentin. Its use in cats and dogs to treat pain is “off label” or “extra label”.
Amantadine is a drug with multiple uses and varied mechanisms of action. It is not licensed for use for pain in dogs but contributes to pain relief by reducing the development of sensitisation to pain in the central nervous system (e.g. brain and spinal cord).
One study in dogs with osteoarthritis-related pain refractory to an NSAID showed that physical activity was improved by the addition of amantadine. 8 Those authors concluded that amantadine might be a useful adjunct therapy for the clinical management of canine osteoarthritic pain.
19 lip 2024 · Amantadine belongs to a class of drugs called “adamantanes,” which are drugs designed to combat influenza A viruses. In veterinary medicine, amantadine comes as a tablet, syrup, and...
Amantadine is an antiviral drug that has multiple antiparkinson mechanisms that include dopamine synthesis, reuptake inhibition and release, D2 receptor modulation, as well as glutamate blocking activity at the NMDA receptor. It has mild beneficial effects on rigidity and bradykinesia.