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13 sie 2024 · The pathophysiology, clinical manifestations, and diagnosis of acetaminophen toxicity in adults will be reviewed here. Treatment of this condition and evaluation of poisoning in children are discussed separately.
When used properly, acetaminophen is a safe, effective analgesic and antipyretic. However, acetaminophen toxicity can lead to hepatotoxicity, liver failure, and death. Critical care nurses play an important role in decreasing morbidity and mortality in these patients.
7 maj 2024 · Acetaminophen poisoning is among the most common causes of medication-related poisoning and death. It may occur following an acute ingestion or through repeated ingestions of supratherapeutic amounts.
Mild poisoning may not cause symptoms, and when present, symptoms of acute acetaminophen poisoning are usually minor until ≥ 48 hours after ingestion. Symptoms, which occur in 4 stages (see table ), include anorexia, nausea, vomiting, and right upper quadrant abdominal pain.
2 lut 2024 · In adults, an acute ingestion of more than 150 mg/kg or 12 g of acetaminophen is considered a toxic dose and poses a high risk of liver damage. In children, acute ingestion of 250 mg/kg or...
9 cze 2023 · The recommended dose of acetaminophen for adults is 650 mg to 1000 mg every 4 to 6 hours, not to exceed 4 grams/day. In children, the dose is 15 mg/kg every 6 hours, up to 60 mg/kg/day. Toxicity develops at 7.5 g/day to 10 g/day or 140 mg/kg.
8 paź 2021 · Acetaminophen toxicity. October 8, 2021 by Josh Farkas. CONTENTS. Rapid Review. Epidemiology & pharmacokinetics. Clinical evolution. Patient evaluation. Decontamination. Who needs treatment? Acetylcysteine. Massive acetaminophen poisoning. Management of established hepatic failure. Management of renal failure. Podcast. Questions & discussion.
