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It is a left-handed double helical structure in which the helix winds to the left in a zigzag pattern, instead of to the right, like the more common B-DNA form. Z-DNA is thought to be one of three biologically active double-helical structures along with A-DNA and B-DNA.
Understanding the impact of the formation of these secondary structures on cellular processes can enable identification of new targets for therapeutics. In this review, we report the state of understanding of Z-DNA structure and formation and their implication in disease.
19 lip 2021 · Z-form DNA. Z-DNA is a radically different duplex structure, with the two strands coiling in left-handed helices and a pronounced zig-zag (hence the name) pattern in the phosphodiester backbone.
16 gru 2019 · Z-DNA is a left-handed double helix, which significantly structurally differs from the right-handed B-duplex. Z-DNA has a coil of 44.6 Å in height, which consists of 12 Watson–Crick base pairs, with the conformations of dG and dC being significantly different.
9 paź 2018 · Structure. Z-DNA (, PDB entry 2acj) can form in vitro from B-DNA by raising negative super helical stress or under low salt conditions when deoxycytosine is 5-methylated. The formation of Z-DNA in vivo is an energy requiring process.
The papers in this Special Issue, “Z-DNA and Z-RNA: from Physical Structure to Biological Function”, are based on presentations at the ABZ2021 meeting that was held virtually on 19 May 2021 and provide evidence for several biological functions of these structures.
14 sty 2023 · In this review, we aim to discuss some of the inherent structural properties of Z-RNA and Z-DNA, and how they affect the Z-DNA/RNA formation, sequence preferences, stability, as well as energetics.
