Search results
Studies have shown that when serum vancomycin levels are maintained above 10 mcg/mL, the emergence of vancomycin intermediate-resistant S. aureus and vancomycin-resistant S. aureus are less likely to develop. 2 Consensus guidelines recommend a target trough concentration of 15 to 20 mcg/mL for clinical success in severe infections. 2 To reach ...
22 lut 2023 · Initial: A single level should be drawn within the first 24-48 hours after the first dose. An earlier initial level may be helpful in ensuring therapeutic concentrations in certain clinical scenarios (i.e. critically ill patients, patients with high or low BMI, etc.)
2 sie 2024 · Appropriate dosing and administration of vancomycin requires consideration of the pathogen and its susceptibility, type and severity of infection, patient weight, and kidney function . The optimal approach to vancomycin dosing and monitoring for invasive methicillin-resistant S. aureus (MRSA) infections is a subject of ongoing controversy and ...
Usually, the first level is drawn 1-2 hours after the vancomycin infusion is complete (referred to as a vancomycin peak) and the vancomycin trough is drawn at the end of the dosing interval (or restated, prior to the next dose of vancomycin).
Minimum serum vancomycin trough concentrations should always be maintained above 10 mg/L to avoid development of resistance. For a pathogen with an MIC of 1 mg/L, the minimum trough concentration would have to be at least 15 mg/L to generate the target AUC:MIC of 400. IIIB Therapeutic vancomycin drug monitoring, Optimal trough concentrations
Reference Range. Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for...
Recommended pre-dose level range: Moderate infections, elderly and in renal impairment: 10-15mg/l. Severe infections e.g. complicated infection, endocarditis, less sensitive MRSA: 15-20mg/L. If levels not in range contact Microbiology for advice.
