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The MDRD GFR Equation estimates glomerular filtration rate based on creatinine and patient characteristics.
The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
W codziennej praktyce przesączanie kłębuszkowe oznacza się m.in. za pomocą skróconej wersji MDRD. Wzór eGFR = 175 x {}S kreat } -1,154 x [wiek] -0,203 x [0,742 -1,154 x [0,742 dla płci żeńskiej] x [1,21 dla rasy czarnej]
GFR - A blood test measures how much blood your kidneys filter each minute, which is known as your glomerular filtration rate (GFR). Urine Albumin - A urine test checks for albumin in your urine. Albumin is a protein that can pass into the urine when the filters in the kidneys are damaged.
Najczęściej wykorzystywany jest wzór MDRD, wg którego eGFR oblicza się na podstawie stężenia kreatyniny w surowicy, wieku, płci i rasy. Im większe stężenie kreatyniny oraz starszy wiek, tym niższa wartość eGFR.
Estimation of Glomerular Filtration Rate. The National Kidney Foundation K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease. Table 12. Definition and Stages of Chronic Kidney disease. NKDEP: GFR Calculators - the new standards. NKDEP: For laboratory professionals.
Subsequently, the MDR was simplified to a 4-variable version (MDRD-4) that included age, sex, ethnicity, and serum creatinine. This 4-variable version was later reexpressed using serum creatinine values that were standardized to reference methods.