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Thus, a ‘weak link theory of aging’ can be formed, where the preferential loss of low affinity, transient, low probability interactions of cellular networks emerges as an important mechanism ...
This theory suggests that age-related random damage primarily affects the overwhelming majority of the low affinity, transient interactions (weak links) in cellular networks leading to increased noise, destabilization and diversity.
We show that random damage of weak links may lead to an increase of noise and an increased vulnerability of cellular networks, and make a comparison between these predictions and the observed behaviour of the emergent properties of cellular networks in aged organisms.
11 cze 2009 · The "weak link theory of aging" proposed by Sőti and Csermely suggests that most of the age-related random damages affect primarily the weak links in the cellular networks [95].
THEORIES OF AGING: There are more than 300 theories of aging, none of them fully explain the aging process. Wear and Tear Theory: Dr. August Weismann, 1882. Cells and tissues gradually and inevitably deteriorate over time.
24 maj 2024 · The interaction and mutual promotion between aging triggers, aging phenotypic characteristics, and inherited or acquired age-related diseases have become key hotspots of interest for scientists to explore anti-aging strategies.
Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.
