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The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na + ) channel. Class II agents are anti- sympathetic nervous system agents.
Learn how antiarrhythmic drugs are classified by mechanism and how they are used for different arrhythmias. The web page explains the basic mechanism of each class, the limitations of the scheme, and the indications for various drugs.
28 lut 2024 · Identify the antiarrhythmic medication classes based on the Vaughan-Williams classification system and cite examples from each class. Apply evidence-based guidelines in selecting antiarrhythmic medications for specific types of arrhythmias.
23 paź 2018 · This article reviews the history and evolution of the Vaughan Williams classification of antiarrhythmic drugs, and proposes a modernized scheme based on the original framework. It covers the pharmacological targets, cellular mechanisms, and clinical implications of established and novel antiarrhythmic agents.
Learn how to classify and use antiarrhythmic drugs based on their effects on cardiac ion channels and membranes. Compare drug dosages, target levels, adverse effects, and comments for each class.
22 paź 2018 · Among his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central to their clinical use. Methods:
23 sie 2021 · Antiarrhythmic drugs are typically classified using the Vaughan Williams classification system, which divides drugs into four classes based on their effect on the cardiac action potential. Many drugs will act via multiple mechanisms. Class I: Block voltage-gated Na channels. Class Ia: Intermediate dissociation. Class Ib: Fast dissociation.
