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28 lut 2024 · Antiarrhythmic medications play a pivotal role in managing various cardiac rhythm disorders, and their classification under the Vaughan-Williams system serves as a cornerstone for understanding their diverse mechanisms of action.
The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na +) channel. Class II agents are anti- sympathetic nervous system agents. Most agents in this class are beta blockers. Class III agents affect potassium (K +) efflux.
Although different classification schemes have been proposed, the first scheme (Vaughan-Williams) is still the one that most physicians use when speaking of antiarrhythmic drugs. The following table shows the classic Vaughan-Williams classification and the basic mechanism of action associated with each class.
22 paź 2018 · Among his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central to their clinical use.
Class Ia. Uses: APB and VPB suppression, SVT and VT suppression, AF or atrial flutter, and VF suppression. IV: Initially, 1.5 mg/kg over > 5 minutes followed by an infusion of 0.4 mg/kg/hour. Oral immediate-release: 100 or 150 mg every 6 hours. Oral controlled-release: 200 or 300 mg every 12 hours.
23 paź 2018 · The Vaughan Williams scheme, for all its limitations in light of subsequent developments in the cardiac elec-trophysiological field, thus remains the most useful, clinically and pedagogically popular approach to cat-egorizing antiarrhythmic drugs.
20 mar 2020 · The Vaughan Williams classification is the most widely recognised system for classifying antiarrhythmic therapies 2 (see Table 3). Medications are categorised depending on where they act within the cardiac action potential (see Figure 1).
