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What are vancomycin levels? Vancomycin serum trough concentrations, levels drawn just before the next scheduled dose, are considered the most practical method for monitoring efficacy when the pathogen is susceptible. 2 Vancomycin peak concentrations, levels from blood specimens obtained 30 to 60 minutes after drug administration, aren't ...
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough...
Typically, we aim for Vancomycin trough levels between 10-20µg/mL (15-20 µg/mL for more severe infections). WHY NOT MEASURE PEAKS? Vancomycin displays time-dependent bactericidal activity when above the minimum inhibitory concentration (MIC), not dose-dependent.
29 wrz 2016 · Recent guidelines have recommended vancomycin trough levels of 15–20 mg/L for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, high trough levels may increase risk of nephrotoxicity and mortality, and high vancomycin trough levels have not been well studied.
16 sty 2019 · Conventional dosing consists of giving a weight-based dose (e.g. 15 mg/kg q12) and then checking a trough level after four doses, targeting a trough of 15-20 mg/L for serious infections. There are numerous reasons this strategy fails, especially among the sickest ICU patients: Trough levels cannot ensure administration of a safe dose.
The 2020 vancomycin therapeutic guidelines recommends a move away from monitoring vancomycin trough levels to targeting an AUC 24:MIC (24-hour area under the curve (AUC) to minimum inhibitory concentration ratio). Dosing vancomycin using trough-only monitoring is no longer recommended.
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
